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New Drug For Skin Cancer Approaching Commercialization




A drug that is activated by light can be a quick, simple, and cheap treatment for tens of thousands of patients with skin cancer in Sweden alone. Researcher Leif Eriksson's team at rebro University in Sweden has now received about SEK 4 million from government research financiers, the Swedish Research Council and Vinnova, to further develop and commercialize the method.


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Photodynamic Therapy for 101 Early Cancers of the Upper Aerodigestive Tract, the Esophagus, and the Bronchi: A Single-Institution Experience
Cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical therapy. We report on the results of our clinical experience with photodynamic therapy (PDT) for the treatment of early carcinomas in the upper aerodigestive tract, the esophagus, and the tracheobronchial tree. Sixty-four patients with 101 squamous cell carcinomas were treated with three different photosensitizers: hematoporphyrin derivative (HPD), Photofrin II, and tetra (m-hydroxyphenyl)chlorin (mTHPC). Seventy-seven (76%) tumors showed a complete rsponse with no recurrence after a mean follow-up period of 27 months. There was no significant difference in terms of cure rates among the three dyes. However, mTHPC has a stronger phototoxicity and induces a shorter skin photosensitization than either of the other photosensitizers. There were eight major complications: three esophagotracheal fistulae after illumination with red light in the esophagus, two esophageal stenoses following 360° circumferential irradiation, and three bronchial stenoses. Illumination with the less penetrating green light and the use of a 180° or 240° windowed cylindrical light distributor render the risk of complications in the esophagus essentially impossible, without reducing the efficacy of the treatment. Therefore, PDT may be considered as a safe and effective treatment for early carcinomas of the upper aerodigestive tract, the esophagus, and the tracheobronchial tree.
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Intelerad Launches InteleOne Solution at RSNA 2008
How can you become more efficient when reading for multiple hospitals and clinics that have different RIS / PACS solutions? InteleOne addresses this issue directly by providing a single worklist, single workflow and a single dictation system for radiologists, no matter where the images originate. This means that: Report turnaround times are substantially improved You are able to bring on additional study volumes without adding radiologists Intelerad will be at RSNA 2008, which takes place on 1 – 5 December in Chicago, Illinois. Visit Intelerad in hall A, booth number 2865, where you ca...
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"Casino Capitalism" One Root of Current Crisis, Says German Economic Expert

Prof. Sinn offered a bleak prognosis of the current U.S. financial crisis during the Continuous Education session, which was moderated by Prof. Xavier Vives, took place at IESE's campus in Barcelona on November 12.

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[Anatomy and Pathology] The Development of the Refractive Status and Ocular Growth in C57BL/6 Mice

Optical coherence tomography with a stepper motor appears useful in the measurement of eye growth in the C57BL/6 mouse model, which showed the axial length and corneal curvature were the major factors for the rapidly increased hyperopic in mouse eyes.

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[Hip] European validation of the Vancouver classification of periprosthetic proximal femoral fractures

The Vancouver classification has been shown by its developers to be a valid and reliable method for categorising the configuration of periprosthetic proximal femoral fractures and for planning their management. We have re-validated this classification system independently using the radiographs of 30 patients with periprosthetic fractures. These were reviewed by six experienced consultant orthopaedic surgeons, six trainee surgeons and six medical students in order to assess intra- and interobserver reliability and reproducibility. Each observer read the radiographs on two separate occasions. The results were subjected to weighted kappa statistical analysis.

The respective kappa values for interobserver agreement were 0.72 and 0.74 for consultants, 0.68 and 0.70 for trainees on the first and second readings of the radiographs and 0.61 for medical students. The intra-observer agreement for the consultants was 0.64 and 0.67, for the trainees 0.61 and 0.64, and for the medical students 0.59 and 0.60 for the first and second readings, respectively. The validity of the classification was studied by comparing the pre-operative radiological findings within B subgroups with the operative findings. This revealed agreement for 77% of these type-B fractures, with a kappa value of 0.67.

Our data confirm the reliability and reproducibility of this classification system in a European setting and for inexperienced staff. This is a reliable system which can be used by non-experts, between centres and across continents.

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Dermatology News From Medical News Today
By editors@medicalnewstoday.com (MNT Editors) - Copyright 2008 Medical News Today - version: v1.5 build A